Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …

Objective Intratumor heterogeneity drives cancer progression and therapy resistance.
However, it has yet to be determined whether and how subpopulations of cancer cells …

The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the
important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable …

Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks.
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …

Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …

Porphyromonas gingivalis is a member of the dysbiotic oral microbiome associated with oral
inflammation and periodontal disease. Intriguingly, epidemiological studies link P. gingivalis …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent …

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks
effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using …

Extensive desmoplasia is a prominent feature of the pancreatic ductal adenocarcinoma
(PDAC) microenvironment. Initially, studies demonstrated that desmoplasia promotes …