[HTML][HTML] Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
[HTML][HTML] Tumor microenvironment participates in metastasis of pancreatic cancer
B Ren, M Cui, G Yang, H Wang, M Feng, L You… - Molecular cancer, 2018 - Springer
Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …
diagnosis and metastasis. The tumor microenvironment induced by interactions between …
[HTML][HTML] Extracellular vesicles from pancreatic cancer stem cells lead an intratumor communication network (EVNet) to fuel tumour progression
CF Ruivo, N Bastos, B Adem, I Batista, C Duraes… - Gut, 2022 - gut.bmj.com
Objective Intratumor heterogeneity drives cancer progression and therapy resistance.
However, it has yet to be determined whether and how subpopulations of cancer cells …
However, it has yet to be determined whether and how subpopulations of cancer cells …
[HTML][HTML] Dual hypoxia-responsive supramolecular complex for cancer target therapy
JS Guo, JJ Li, ZH Wang, Y Liu, YX Yue, HB Li… - Nature …, 2023 - nature.com
The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the
important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable …
important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable …
The impact of hypoxia on immune state in cancer
K Mortezaee, J Majidpoor - Life sciences, 2021 - Elsevier
Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks.
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …
[HTML][HTML] Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going
C Liang, S Shi, Q Meng, D Liang, S Ji… - … & molecular medicine, 2017 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …
[HTML][HTML] Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells
JM Gnanasekaran, A Binder Gallimidi, E Saba, K Pandi… - Cancers, 2020 - mdpi.com
Porphyromonas gingivalis is a member of the dysbiotic oral microbiome associated with oral
inflammation and periodontal disease. Intriguingly, epidemiological studies link P. gingivalis …
inflammation and periodontal disease. Intriguingly, epidemiological studies link P. gingivalis …
[HTML][HTML] The ever-evolving concept of the cancer stem cell in pancreatic cancer
S Valle, L Martin-Hijano, S Alcalá, M Alonso-Nocelo… - Cancers, 2018 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent …
the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent …
Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast–driven nutritional support and immunosuppression
R Francescone, D Barbosa Vendramini-Costa… - Cancer discovery, 2021 - AACR
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks
effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using …
effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using …
[HTML][HTML] Desmoplasia in pancreatic ductal adenocarcinoma: insight into pathological function and therapeutic potential
Extensive desmoplasia is a prominent feature of the pancreatic ductal adenocarcinoma
(PDAC) microenvironment. Initially, studies demonstrated that desmoplasia promotes …
(PDAC) microenvironment. Initially, studies demonstrated that desmoplasia promotes …