The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

The incorporation of the “magic” boron atom has been established as an important new
strategy in the field of medicinal chemistry as boron compounds have been shown to form …

β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

Klebsiella pneumoniae as a main opportunistic pathogen is a common cause of health-care-
associated bacterial infections, which has shown high levels of drug resistance specifically …

The SARS-CoV-2 main protease (Mpro) is a medicinal chemistry target for COVID-19
treatment. Given the clinical efficacy of β-lactams as inhibitors of bacterial nucleophilic …

The problem of multidrug resistance in bacterial pathogens is significant and is related to the
high morbidity and death rates of living things due to increased levels of beta-lactamases …

Antimicrobial resistance (AMR) is a leading cause of treatment failure for many infectious
diseases worldwide. Improper overdosing and the misuse of antibiotics contributes …

Carbapenem-resistant Enterobacterales, such as KPC-producing Klebsiella pneumoniae,
represent a major threat to public health. Novel drug combinations including imipenem …

The increasing emergence of bacteria producing β-lactamases enzymes (BLEs), able to
inactivate the available β-lactam antibiotics (BLAs), causing the hydrolytic opening of their β …

Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes
have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One …