The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases

T Efferth, F Oesch - Medicinal research reviews, 2021 - Wiley Online Library
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

Shikonin derivatives for cancer prevention and therapy

JC Boulos, M Rahama, MEF Hegazy, T Efferth - Cancer letters, 2019 - Elsevier
Phytochemicals gained considerable interest during the past years as source to develop
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …

Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning

O Kadioglu, M Saeed, HJ Greten, T Efferth - Computers in biology and …, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a major threat worldwide due to its fast
spreading. As yet, there are no established drugs available. Speeding up drug discovery is …

Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

R Bergquist, J Utzinger, J Keiser - Infectious diseases of poverty, 2017 - Springer
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty
with considerable public health and socioeconomic impact, is based on preventive …

[HTML][HTML] Artemisinin, the magic drug discovered from traditional Chinese medicine

J Wang, C Xu, YK Wong, Y Li, F Liao, T Jiang, Y Tu - Engineering, 2019 - Elsevier
Artemisinin and its derivatives represent the most important and influential class of drugs in
the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global …

Beyond malaria: The inhibition of viruses by artemisinin-type compounds

T Efferth - Biotechnology advances, 2018 - Elsevier
Natural products represent valuable chemical scaffolds for drug development. A recent
success story in this context was artemisinin, which is not only active against malaria but …

Advances in the research on the targets of anti-malaria actions of artemisinin

J Yang, Y He, Y Li, X Zhang, YK Wong, S Shen… - Pharmacology & …, 2020 - Elsevier
Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …

Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

SS Santos, RV de Araújo, J Giarolla, O El Seoud… - International journal of …, 2020 - Elsevier
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

A concise review on Artemisia annua L.: A major source of diverse medicinal compounds

R Soni, G Shankar, P Mukhopadhyay… - Industrial Crops and …, 2022 - Elsevier
Malaria is one of the major global health concerns that affect millions of people worldwide
annually, especially people residing in the developing countries. The previously …

Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents

A Trendafilova, LM Moujir, PMC Sousa, AML Seca - Foods, 2020 - mdpi.com
The genus Artemisia, often known collectively as “wormwood”, has aroused great interest in
the scientific community, pharmaceutical and food industries, generating many studies on …