Malignant peritoneal mesothelioma (MPM) is a rare neoplasm of the peritoneum, causally
related to asbestos exposure. Nonspecific symptoms with a late diagnosis results in poor …

Systemic enzyme therapy was recently subjected to experimental investigations and to
rigorous clinical studies in cancer patients. The designs of the relevant clinical cohort studies …

This study hypothesizes that, bromelain (BL) acts as radiosensitizer of tumor cells and that it
protects normal cells from radiation effects. In vitro and in vivo studies have been carried out …

Cancer and autoimmune diseases are the two devastating conditions that together
constitute a leading health problem worldwide. The rising burden of these disorders in the …

Bromelain has been reported to have anti-inflammatory and immunomudulatory effects. It
has been cross-linked with organic acids and polysaccharides by γ irradiation. The cross …

Breast cancer (BC) remains the leading cause of death in women worldwide, despite the
improvements of cancer screening and treatment methods. Recently, development of novel …

Soft tissue sarcomas (STS) are rare mesenchymal neoplasms comprising 1% of the global
burden of malignant cancers. Adjuvant chemotherapy includes doxorubicin with or without …

Papain is a proteolytic enzyme obtained from the fruits of carica papaya with abundant
therapeutic, food, industrial and analytical applications. The challenges related to the …

Bromelain is one of the proteolytic enzymes found in pineapple stems and fruits. It has been
investigated for medical uses including anti-cancer activity. The objective of this study was to …

BACKGROUND: Bromelain is a sulfhydryl proteolytic enzyme that can hydrolyze protein,
protease or peptide. Bromelain can be found in pineapple stem, fruit and core. Bromelain is …