Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …

Baseline physiological function of the mammalian heart is under the constant threat of
environmental or intrinsic pathological insults. Cardiomyocyte proteins are thus subject to …

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG
trinucleotide repeat in the huntingtin gene (HTT). Molecular chaperones have been …

Spinocerebellar ataxias (SCAs) represent a large group of hereditary degenerative diseases
of the nervous system, in particular the cerebellum, and other systems that manifest with a …

Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated
disorders characterized by the disruption of cellular proteostasis machinery and the …

Age‐dependent neurodegenerative diseases progressively form aggregates containing
both shared components (eg, TDP‐43, phosphorylated tau) and proteins specific to each …

Oxygen is fundamentally important for cell metabolism, and as a consequence, O2
deprivation (hypoxia) can impair many essential physiological processes. Here, we show …

Expanded polyglutamine repeats in different proteins are the known determinants of at least
nine progressive neurodegenerative disorders whose symptoms include cognitive and …

The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic
lateral sclerosis (ALS), Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's …

ABSTRACT Introduction Cerebellar ataxias (CAs) represent neurological disorders with
multiple etiologies and a high phenotypic variability. Despite progress in the understanding …