Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment

P Chotiyarnwong, EV McCloskey - Nature Reviews Endocrinology, 2020 - nature.com
Glucocorticoids are widely used to suppress inflammation or the immune system. High
doses and long-term use of glucocorticoids lead to an important and common iatrogenic …

Secondary osteoporosis

PR Ebeling, HH Nguyen, J Aleksova… - Endocrine …, 2022 - academic.oup.com
Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

[HTML][HTML] The clinician's guide to prevention and treatment of osteoporosis

MS LeBoff, SL Greenspan, KL Insogna… - Osteoporosis …, 2022 - Springer
Osteoporosis is the most common metabolic bone disease in the USA and the world. It is a
subclinical condition until complicated by fracture (s). These fractures place an enormous …

Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?

R Pofi, G Caratti, DW Ray, JW Tomlinson - Endocrine Reviews, 2023 - academic.oup.com
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Involvement of the gut microbiota and barrier function in glucocorticoid‐induced osteoporosis

JD Schepper, F Collins, ND Rios‐Arce… - Journal of Bone and …, 2020 - Wiley Online Library
Glucocorticoids (GCs) are potent immune‐modulating drugs with significant side effects,
including glucocorticoid‐induced osteoporosis (GIO). GCs directly induce osteoblast and …

Pathogenic mechanisms of glucocorticoid-induced osteoporosis

M Chen, W Fu, H Xu, C Liu - Cytokine & growth factor reviews, 2023 - Elsevier
Glucocorticoid (GC) is one of the most prescribed medicines to treat various inflammatory
and autoimmune diseases. However, high doses and long-term use of GCs lead to multiple …

SARS-CoV-2 and its multifaceted impact on bone health: mechanisms and clinical evidence

A Harris, A Creecy, OD Awosanya, T McCune… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic,
has been associated with significant long-term effects on various organ systems, including …

The treatment gap in osteoporosis

N Ayub, M Faraj, S Ghatan, JAA Reijers… - Journal of clinical …, 2021 - mdpi.com
Worldwide, there are millions of people who have been diagnosed with osteoporosis, a
bone disease that increases the risk of fracture due to low bone mineral density and …

A mini review on osteoporosis: From biology to pharmacological management of bone loss

KY Chin, BN Ng, MKI Rostam… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …