New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury

M Cinausero, G Aprile, P Ermacora, D Basile… - Frontiers in …, 2017 - frontiersin.org
Mucositis is a common complication of chemotherapy, radiotherapy and targeted agents. It
often affects compliance to anticancer therapies as it frequently causes schedule delays …

Pathophysiology of radiation-induced dysphagia in head and neck cancer

SN King, NE Dunlap, PA Tennant, T Pitts - Dysphagia, 2016 - Springer
Oncologic treatments, such as curative radiotherapy and chemoradiation, for head and neck
cancer can cause long-term swallowing impairments (dysphagia) that negatively impact …

A phase II randomized clinical trial and mechanistic studies using improved probiotics to prevent oral mucositis induced by concurrent radiotherapy and chemotherapy …

C Xia, C Jiang, W Li, J Wei, H Hong, J Li… - Frontiers in …, 2021 - frontiersin.org
Earlier evidence has proven that probiotic supplements can reduce concurrent
chemoradiotherapy (CCRT)-induced oral mucositis (OM) in nasopharyngeal cancer (NPC) …

Oral pain in the cancer patient

JB Epstein, C Miaskowski - JNCI Monographs, 2019 - academic.oup.com
Oral pain due to cancer and associated treatments is common. The prevalence and severity
of oral cancer is high. Painful oral mucositis develops in head and neck cancer patients …

Pharmacological management of neuropathic pain after radiotherapy in head and neck cancer patients: a systematic review

M Kouri, M Rekatsina, A Vadalouca, I Siafaka… - Journal of Clinical …, 2022 - mdpi.com
Background: Neuropathic pain (NP) in head and neck cancer (HNC) patients represents a
treatment challenge. Most studies investigating drugs against NP are conducted in patients …

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

DE Peterson, JA O'Shaughnessy, HS Rugo… - Cancer …, 2016 - Wiley Online Library
In recent years oral mucosal injury has been increasingly recognized as an important toxicity
associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with …

Neurotrophin pathway receptors NGFR and TRKA control perineural invasion, metastasis, and pain in oral cancer

C Doan, BE Aouizerat, Y Ye, D Dang, K Asam… - Advanced …, 2022 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) patients suffer from poor survival due to metastasis
or locoregional recurrence, processes that are both facilitated by perineural invasion (PNI) …

Distinct TRPV1-and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil

K Yamaguchi, K Ono, S Hitomi, M Ito, T Nodai, T Goto… - Pain, 2016 - journals.lww.com
In many patients with cancer, chemotherapy-induced severe oral ulcerative mucositis
causes intractable pain, leading to delays and interruptions in therapy. However, the pain …

[HTML][HTML] Cancer and orofacial pain

M Romero-Reyes, D Salvemini - Medicina Oral, Patología Oral y …, 2016 - ncbi.nlm.nih.gov
Background Cancer pain is a devastating condition. Pain in the orofacial region, may be
present as the single symptom of cancer or as a symptom of cancer in its later stages. This …

Sprayable NAHAO® hydrogel alleviates pain and accelerates rat oral mucositis wound healing

Y Zhao, R Mao, H Yan, Y Zhang, H Ma… - Journal of Stomatology …, 2023 - Elsevier
Objective To investigate the promote healing and analgesic effects of NAHAO® Brand
Nazhen oral antibacterial care solution (NAHAO® spray) on the 5-fluorouracil-induced oral …