Recent clinical trials have now firmly established that inflammation participates causally in
human atherosclerosis. These observations point the way toward novel treatments that add …

Despite major advances in prevention and treatment, cardiac and cerebral atherothrombotic
complications still account for substantial morbidity and mortality worldwide. In this context …

Background Prompt myocardial revascularization with percutaneous coronary intervention
(PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation …

Background: Patients experiencing out-of-hospital cardiac arrest who remain comatose after
initial resuscitation are at high risk of morbidity and mortality attributable to the ensuing post …

Acute coronary syndrome (ACS) is a major cause of acute death worldwide. Both innate and
adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus …

Cardiovascular disease is the leading cause of death worldwide, and its prevalence is
increasing due to the aging of societies. Atherosclerosis, a type of chronic inflammatory …

Background We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves
myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the …

Genome wide association, epidemiological, and clinical studies have established high
lipoprotein (a)[Lp (a)] as a causal risk factor for atherosclerotic cardiovascular disease …

Circulating apolipoprotein B-containing lipoproteins, notably the low-density lipoproteins,
enter the inner layer of the arterial wall, the intima, where a fraction of them is retained and …

Introduction Achieving reperfusion immediately after acute myocardial infarction improves
outcomes; despite this, patients remain at a high risk for mortality and morbidity at least for …