Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

Chemotherapy is still one of the principal treatments for gastric cancer, but the clinical
application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis …

The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …

Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor
suppressing process. However, functions and mechanisms of RNA-binding proteins in …

Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Ferroptosis is a new form of programmed cell death characterized by the accumulation of
iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that …

Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Pharmacologic inhibition of PARP is the primary therapeutic strategy for BRCA mutant
ovarian cancer. However, most of patients carry wild-type BRCA1/2 with no significant …