Gap junctions and connexin-interacting proteins

BNG Giepmans - Cardiovascular research, 2004 - academic.oup.com
Gap junctions form channels between adjacent cells. The core proteins of these channels
are the connexins. Regulation of gap junction communication (GJC) can be modulated by …

[HTML][HTML] Regulation of connexin biosynthesis, assembly, gap junction formation, and removal

D Segretain, MM Falk - Biochimica et Biophysica Acta (BBA) …, 2004 - Elsevier
Gap junctions (GJs) are the only known cellular structures that allow a direct transfer of
signaling molecules from cell-to-cell by forming hydrophilic channels that bridge the …

Connexin-specific distribution within gap junctions revealed in living cells

MM Falk - Journal of cell science, 2000 - journals.biologists.com
To study the organization of gap junctions in living cells, the connexin isotypes α1 (Cx43), β1
(Cx32) and β2 (Cx26) were tagged with the autofluorescent tracer green fluorescent protein …

Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes

M Kaneda, MN Shin-ichiro, S Ichinose, S Kondo… - Biomaterials, 2009 - Elsevier
Liposomes are widely utilized in molecular biology and medicine as drug carriers. Here we
report a new liposome–cell interaction through connexins. Connexin 43 (Cx43)-containing …

Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?

M De Bock, M Kerrebrouck, N Wang… - Frontiers in …, 2013 - frontiersin.org
The coordination of tissue function is mediated by gap junctions (GJs) that enable direct cell–
cell transfer of metabolic and electric signals. GJs are formed by connexins of which Cx43 is …

Biosynthesis and structural composition of gap junction intercellular membrane channels

MM Falk - European journal of cell biology, 2000 - Elsevier
Gap junction channels assemble as dodecameric complexes, in which a hexameric
connexon (hemichannel) in one plasma membrane docks end-to-end with a connexon in …

Intracellular cleavage of the Cx43 C‐terminal domain by matrix‐metalloproteases: a novel contributor to inflammation?

M De Bock, N Wang, E Decrock… - Mediators of …, 2015 - Wiley Online Library
The coordination of tissue function is mediated by gap junctions (GJs) that enable direct cell‐
cell transfer of metabolic and electric signals. GJs are formed by connexin (Cx) proteins of …

Comparative analysis of Cx31 and Cx43 in differentiation-competent rodent keratinocytes

A Au, Q Shao, KK White, SA Lucaciu, JL Esseltine… - Biomolecules, 2020 - mdpi.com
When considering connexin expression and regulation, the epidermis of the skin is one of
the most complex tissues found in mammals even though it largely contains a single cell …

Heteromerization of Innexin Gap Junction Proteins Regulates Epithelial Tissue Organization in Drosophila

C Lehmann, H Lechner, B Loer, M Knieps… - Molecular biology of …, 2006 - Am Soc Cell Biol
Gap junctions consist of clusters of intercellular channels, which enable direct cell-to-cell
communication and adhesion in animals. Whereas deuterostomes, including all vertebrates …

High resolution, fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap …

MM Falk, U Lauf - Microscopy research and technique, 2001 - Wiley Online Library
High‐resolution, fluorescence deconvolution (DV) microscopy was implemented to obtain a
detailed view of the organization and structural composition of gap junctions assembled …