Current challenges and unmet medical needs in myelodysplastic syndromes

U Platzbecker, AS Kubasch, C Homer-Bouthiette… - Leukemia, 2021 - nature.com
Myelodysplastic syndromes (MDS) represent a heterogeneous group of myeloid neoplasms
that are characterized by ineffective hematopoiesis, variable cytopenias, and a risk of …

[HTML][HTML] Hematopoietic cell transplantation in the management of myelodysplastic syndrome: an evidence-based review from the American Society for Transplantation …

Z DeFilipp, SO Ciurea, C Cutler, M Robin… - … and Cellular Therapy, 2023 - Elsevier
The sole curative therapy for myelodysplastic syndrome (MDS) is allogeneic hematopoietic
cell transplantation (HCT). Here this therapeutic modality is reviewed and critically evaluated …

Relapse and disease-free survival in patients with myelodysplastic syndrome undergoing allogeneic hematopoietic cell transplantation using older matched sibling …

GSG Murthy, S Kim, ZH Hu, N Estrada-Merly… - JAMA …, 2022 - jamanetwork.com
Importance Matched sibling donors (MSDs) are preferred for allogeneic hematopoietic cell
transplantation (allo-HCT) in myelodysplastic syndrome even if they are older. However …

Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International …

M Stahl, JP Bewersdorf, Z Xie, MGD Porta, R Komrokji… - Blood Reviews, 2023 - flore.unifi.it
The guidelines for classification, prognostication, and response assessment of
myelodysplastic syndromes/neo-plasms (MDS) have all recently been updated. In this report …

Allogeneic stem cell transplantation for patients with myelodysplastic syndromes

P Vittayawacharin, P Kongtim… - American Journal of …, 2023 - Wiley Online Library
Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem
cell neoplasms primarily affecting older persons, associated with dysplastic changes of bone …

BMT for myelodysplastic syndrome: when and where and how

AG Jain, H Elmariah - Frontiers in Oncology, 2022 - frontiersin.org
Myelodysplastic syndromes (MDS) are a diverse group of hematological malignancies
distinguished by a combination of dysplasia in the bone marrow, cytopenias and the risk of …

Prognostication in myelodysplastic syndromes (neoplasms): molecular risk stratification finally coming of age

Z Xie, EC Chen, M Stahl, AM Zeidan - Blood Reviews, 2023 - Elsevier
Accurate risk prognostication is central to the management of myelodysplastic syndromes,
given the widely heterogeneous clinical outcomes of these bone marrow failure disorders …

Updates in classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): a state-of-the-art report on behalf of the …

M Stahl, JP Bewersdorf, Z Xie, MG Della Porta… - Blood Reviews, 2023 - Elsevier
The guidelines for classification, prognostication, and response assessment of
myelodysplastic syndromes/neoplasms (MDS) have all recently been updated. In this report …

Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients

Y Shimomura, M Hara, T Konuma, H Itonaga… - Bone Marrow …, 2021 - nature.com
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment
option for adolescent and young adult (AYA) patients with myelodysplastic syndrome (MDS) …

Does IPSS-R downstaging before transplantation improve the prognosis of patients with myelodysplastic neoplasms?

C Scheid, DJ Eikema, M Van Gelder, U Salmenniemi… - Blood, 2024 - ashpublications.org
In patients with myelodysplastic syndrome (MDS), higher revised International Prognostic
Scoring System (IPSS-R) scores at transplant are associated with worse transplant outcome …