Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …

Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …

The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester
bond at the sn-2 position of the phospholipids, generating a free fatty acid and a …

Phospholipids are suggested to drive tumorigenesis through their essential role in
inflammation. Phospholipase A2 (PLA2) is a phospholipid metabolizing enzyme that …

Necrosis that appears at the ischemic distal end of random-pattern skin flaps increases the
pain and economic burden of patients. Necroptosis is thought to contribute to flap necrosis …

Cardiovascular disease is the leading cause of human death worldwide. Drug thrombolysis,
percutaneous coronary intervention, coronary artery bypass grafting and other methods are …

Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical
and biochemical features, but require specialized pathways of biosynthesis and …

Lipid droplets, classically regarded as static storage organelles, are currently considered as
dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and …