The hazard function plays a central role in survival analysis. In a homogeneous population,
the distribution of the time to event, described by the hazard, is the same for each individual …

Clinical prediction rules (CPRs) that predict the absolute risk of a clinical condition or future
outcome for individual patients are abundant in the medical literature; however, systematic …

Glomerular filtration rate (GFR) decline is causally associated with kidney failure and is a
candidate surrogate endpoint for clinical trials of chronic kidney disease (CKD) progression …

Importance Acute kidney injury (AKI) occurs in up to half of patients hospitalized with
coronavirus disease 2019 (COVID-19). The longitudinal effects of COVID-19–associated AKI …

Background Mortality in acute respiratory failure remains high despite the use of lung-
protective ventilation. Recent studies have shown an association between baseline …

Despite recent therapeutic advances, multiple myeloma (MM) remains largely incurable.
Here we report results of a phase I/II trial to evaluate the safety and activity of autologous T …

Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

Abstract Introduction The LipiDiDiet trial investigates the effects of the specific multinutrient
combination Fortasyn Connect on cognition and related measures in prodromal Alzheimer's …

The R package lcmm provides a series of functions to estimate statistical models based on
linear mixed model theory. It includes the estimation of mixed models and latent class mixed …

Missing data affect nearly every discipline by complicating the statistical analysis of collected
data. But since the 1990s, there have been important developments in the statistical …