Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …

White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …

CD44 is a transmembrane glycoprotein linked to various biological processes reliant on
epigenetic plasticity, which include development, inflammation, immune responses, wound …

Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various
metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia …

Neurotransmitters have been well documented to determine immune cell fates; however,
whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is …

Intermediary metabolism generates substrates for chromatin modification, enabling the
potential coupling of metabolic and epigenetic states. Here we identify a network linking …

Cell state transitions control the functional behavior of cancer cells. Epithelial-to-
mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced …

Summary H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments.
They mainly harbor H3. 3K27M mutations resulting in H3K27me3 reduction. Integrated …

Mitochondria are membrane-enclosed organelles with endosymbiotic origins, harboring
independent genomes and a unique biochemical reaction network. To perform their critical …

Trained immunity is a process in which innate immune cells undergo functional
reprogramming in response to pathogens or damage‐associated molecules leading to an …