Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …

Metabolites have functions in the immune system independent of their conventional roles as
sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering …

For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying
crucial biomarkers responsible for metabolic characteristics and revealing metabolic …

Fluorogenic RNA aptamers are used to genetically encode fluorescent RNA and to construct
RNA-based metabolite sensors. Unlike naturally occurring aptamers that efficiently fold and …

Pluripotent stem cells (PSCs) can self-renew or differentiate from naive or more
differentiated, primed, pluripotent states established by specific culture conditions. Increased …

Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic
transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …