Dynamic regulation of gene expression in response to changing local conditions is critical
for the survival of all organisms. In metazoans, coherent regulation of gene expression …

Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma,
the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are …

To make the appropriate developmental decisions or maintain homeostasis, cells and
organisms must coordinate the expression of their genome and metabolic state. However …

The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …

Fibroblast to myofibroblast differentiation is crucial for the initial healing response but
excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to …

Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers in the
human population. HCC is an inflammation-associated cancer caused by different …

IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …

Cell fate determination requires faithful execution of gene expression programs, which are
increasingly recognized to respond to metabolic inputs. In particular, the family of α …

Cellular metabolism has emerged as a major biological node governing cellular behaviour.
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …

The heart switches its energy substrate from glucose to fatty acids at birth, and maternal
hyperglycemia is associated with congenital heart disease. However, little is known about …