The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by
hexokinase. However, the Glc-6-P produced can then enter one or more of several …

Cell survival has been closely linked to both trophic growth factor signaling and cellular
metabolism. Such couplings have obvious physiologic and pathophysiologic implications …

The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess
two mechanistically similar systems to prevent the generation of mitochondrial reactive …

2.2. 2. Changes in intracellular ion concentrations 3. Energy parameters and changes
therein during increased activity, hypoglycemia and hypoxia/ischemia L 1. Alterations in …

The mitochondrial outer membrane acts as a molecular filter for hydrophilic solutes since it is
freely permeable to a variety of small hydrophilic solutes, but retains molecules with higher …

The transfer of a phosphoryl moiety from ATP to an acceptor group is an essential step,
frequently the initial step, in the metabolism of many molecules. Hence, kinases represent a …

Previous studies from this laboratory have shown that mitochondrial bound hexokinase is
markedly elevated in highly glycolytic hepatoma cells (Parry, DM, and Pedersen, PL (1983) …

Complexes between hexokinase, outer membrane porin, and the adenylate translocator
(ANT) were recently found to establish properties of the mitochondrial permeability transition …

Physiologically, a postprandial glucose rise induces metabolic signal sequences that use
several steps in common in both the pancreas and peripheral tissues but result in different …

Defects in liver and muscle glycogen synthesis are major factors contributing to
postprandrial hyperglycemia in patients with type 2 diabetes. Therefore, activation of …