As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Importance Given the burden of chronic liver disease on the health care system, more
information on the hepatoprotective association of statins in the general population is …

Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity,
diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease …

Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Lung cancer is a common neoplasm, usually treated through chemotherapy, radiotherapy
and/or surgery. Both clinical and experimental studies on cancer cells suggest that some …

Various factors limit the use of simvastatin as an anticancer drug. Therefore, this study aimed
to analyse simvastatin (SIM)-loaded cubosome efficacy against breast cancer. SIM-loaded …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by
motoneuron loss, for which there is currently no effective treatment. Statins, as inhibitors of 3 …

Background: Statins have emerged as a vital therapeutic option for dyslipidemia, effectively
reducing morbidity and mortality in individuals with various medical conditions. Recent …

Breast cancer is the most frequent cancer and the second leading cause of death among
women. Triple-negative breast cancer is the most aggressive subtype of breast cancer and …