Mitochondria are membrane-enclosed organelles with endosymbiotic origins, harboring
independent genomes and a unique biochemical reaction network. To perform their critical …

ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis.
It represents a central trafficking hub that sorts proteins and lipids to various destinations or …

Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic
functions. However, how mitochondria sense the abundance of metabolites and regulate …

Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins
encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a …

Organelle transporters define metabolic compartmentalization, and how this metabolite
transport process can be modulated is poorly explored. Here, we discovered that human …

One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …

Heightened concentrations of reactive metabolites, including reactive oxygen species
(ROS), can damage all macromolecules leading to the erosion of cellular fidelity. In this …

Metabolic engineering has witnessed remarkable advancements, enabling successful large-
scale, cost-effective and efficient production of numerous compounds. However, the …

With the rapid development of synthetic biology, various kinds of microbial cell factories
(MCFs) have been successfully constructed to produce high-value-added compounds …