In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

Abstract p38 MAPKs play a central role in orchestrating the cellular response to stress and
inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have …

Rationale: Many viral infections are known to activate the p38 mitogen-activated protein
kinase (MAPK) signaling pathway. However, the role of p38 activation in viral infection and …

Advances in the molecular understanding of facioscapulohumeral muscular dystrophy
(FSHD) have revealed that FSHD results from epigenetic de-repression of the DUX4 gene in …

Abstract Purpose of Review: This article describes the clinical characteristics, diagnosis,
molecular pathogenesis, and treatment of facioscapulohumeral muscular dystrophy (FSHD) …

In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4)
has gone from being an obscure entity to being a key factor in important physiological and …

Whilst a disease-modifying treatment for Facioscapulohumeral muscular dystrophy (FSHD)
does not exist currently, recent advances in complex molecular pathophysiology studies of …

Facioscapulohumeral muscular dystrophy (FSHD) is a disabling inherited muscular disorder
characterized by asymmetric, progressive muscle weakness and degeneration. Patients …

Facioscapulohumeral muscular dystrophy (FSHD), a common hereditary myopathy, is
caused either by the contraction of the D4Z4 macrosatellite repeat at the distal end of …

Advances in understanding the pathophysiology of facioscapulohumeral dystrophy (FSHD)
have led to the discovery of candidate therapeutics, and it is important to identify markers of …