As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer's disease (AD)
and are associated with accelerated cognitive impairment and earlier deaths. This review …

Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity
and quality occur as we age, and are there functional consequences? What are the …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's
disease (AD). Thus far, microglia have rather been known as modulator of …

Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Introduction We evaluated the clinical profile of the orexin receptor antagonist suvorexant for
treating insomnia in patients with mild‐to‐moderate probable Alzheimer's disease (AD) …

The amyloid hypothesis has dominated Alzheimer's disease (AD) research for almost 30
years. This hypothesis hinges on the predominant clinical role of the amyloid beta (Aβ) …