Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
Nanobodies: from structure to applications in non-injectable and bispecific biotherapeutic development
B Li, X Qin, LZ Mi - Nanoscale, 2022 - pubs.rsc.org
The increasing demand for convenient, miniaturized and multifunctional antibodies
necessitates the development of novel antigen-recognition molecules for biological and …
necessitates the development of novel antigen-recognition molecules for biological and …
The potential of nanobodies for COVID-19 diagnostics and therapeutics
DB Naidoo, AA Chuturgoon - Molecular Diagnosis & Therapy, 2023 - Springer
The infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
causative agent for coronavirus disease 2019 (COVID-19). Globally, there have been …
causative agent for coronavirus disease 2019 (COVID-19). Globally, there have been …
Therapeutic applications of nanobodies against SARS-CoV-2 and other viral infections: Current update
M Bhattacharya, S Chatterjee, SS Lee… - International Journal of …, 2023 - Elsevier
In the last two years, the world encountered the SARS-CoV-2 virus, which is still dominating
the population due to the absence of a viable treatment. To eradicate the global pandemic …
the population due to the absence of a viable treatment. To eradicate the global pandemic …
A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron …
The identification of a novel class of shark‐derived single domain antibodies, named
vnarbodies that show picomolar affinities binding to the receptor binding domain (RBD) of …
vnarbodies that show picomolar affinities binding to the receptor binding domain (RBD) of …
[HTML][HTML] Identification of nurse shark VNAR single-domain antibodies targeting the spike S2 subunit of SARS-CoV-2
J Buffington, Z Duan, HJ Kwon, J Hong… - … : official publication of …, 2023 - ncbi.nlm.nih.gov
SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Antibody-based
therapeutics targeting the spike protein, specifically the S1 subunit or the receptor binding …
therapeutics targeting the spike protein, specifically the S1 subunit or the receptor binding …
Next generation single-domain antibodies against respiratory zoonotic RNA viruses
IC Swart, W Van Gelder, CAM De Haan… - Frontiers in Molecular …, 2024 - frontiersin.org
The global impact of zoonotic viral outbreaks underscores the pressing need for innovative
antiviral strategies, particularly against respiratory zoonotic RNA viruses. These viruses …
antiviral strategies, particularly against respiratory zoonotic RNA viruses. These viruses …
Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern
T Kondo, K Matsuoka, S Umemoto… - Life Science …, 2022 - life-science-alliance.org
Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) are useful for patients' treatment of the coronavirus disease 2019 (COVID-19). We …
CoV-2) are useful for patients' treatment of the coronavirus disease 2019 (COVID-19). We …
Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes
Z Sun, L Wang, L Li, Y Sun, D Zhang, S Zhou… - Journal of Structural …, 2023 - Elsevier
Abstract The evolving SARS-CoV-2 Omicron strain has repeatedly caused widespread
disease epidemics, and effective antibody drugs continue to be in short supply. Here, we …
disease epidemics, and effective antibody drugs continue to be in short supply. Here, we …
Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications
The global challenges posed by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic have underscored the critical importance of innovative and …
(SARS-CoV-2) pandemic have underscored the critical importance of innovative and …