The developmental and epileptic encephalopathies encompass a group of rare syndromes
characterised by severe drug-resistant epilepsy with onset in childhood and significant …

Developmental and epileptic encephalopathies are rare, treatment-resistant epilepsies with
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …

Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …

Alzheimer's disease (AD) and epilepsy are common neurological disorders in the elderly. A
bi-directional link between these neurological diseases has been reported, with patients …

Objective To evaluate whether fenfluramine (FFA) is associated with improvement in
everyday executive function (EF)—self-regulation—in preschool-aged children with Dravet …

Objective This study was undertaken to evaluate the long‐term safety and effectiveness of
fenfluramine in patients with Lennox–Gastaut syndrome (LGS). Methods Eligible patients …

Topiramate (TPM) is widely used as monotherapy or add-on therapy in adults and children
(aged 2 to 16 years) with primary generalized tonic-clonic seizures or focal-onset seizures …

Introduction Nearly one-third of all infants with epilepsy develop drug-resistant epilepsy.
Although epilepsy surgery is a well-established therapy across all age groups, there might …

Disorders of autonomic functions are typically characterized by disturbances in multiple
organ systems. These disturbances are often comorbidities of common and rare diseases …

Objective This systematic review aimed to assess the intellectual outcome of children who
underwent surgery for epilepsy. Methods A systematic review of electronic databases was …