Psychobehavioural and cognitive adverse events of anti-seizure medications for the treatment of developmental and epileptic encephalopathies
A Strzelczyk, S Schubert-Bast - CNS drugs, 2022 - Springer
The developmental and epileptic encephalopathies encompass a group of rare syndromes
characterised by severe drug-resistant epilepsy with onset in childhood and significant …
characterised by severe drug-resistant epilepsy with onset in childhood and significant …
Fenfluramine: a plethora of mechanisms?
J Sourbron, L Lagae - Frontiers in pharmacology, 2023 - frontiersin.org
Developmental and epileptic encephalopathies are rare, treatment-resistant epilepsies with
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
F Perversi, C Costa, A Labate, S Lattanzi… - Frontiers in …, 2023 - frontiersin.org
Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …
Antiseizure medications in Alzheimer's disease from preclinical to clinical evidence
F Bosco, L Guarnieri, V Rania, E Palma… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) and epilepsy are common neurological disorders in the elderly. A
bi-directional link between these neurological diseases has been reported, with patients …
bi-directional link between these neurological diseases has been reported, with patients …
[HTML][HTML] Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (< 5 years) with Dravet syndrome: a critical …
KI Bishop, PK Isquith, GA Gioia, KG Knupp… - Epilepsy & Behavior, 2023 - Elsevier
Objective To evaluate whether fenfluramine (FFA) is associated with improvement in
everyday executive function (EF)—self-regulation—in preschool-aged children with Dravet …
everyday executive function (EF)—self-regulation—in preschool-aged children with Dravet …
Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label …
KG Knupp, IE Scheffer, B Ceulemans, J Sullivan… - …, 2023 - Wiley Online Library
Objective This study was undertaken to evaluate the long‐term safety and effectiveness of
fenfluramine in patients with Lennox–Gastaut syndrome (LGS). Methods Eligible patients …
fenfluramine in patients with Lennox–Gastaut syndrome (LGS). Methods Eligible patients …
[HTML][HTML] Molecular mechanisms of topiramate and its clinical value in epilepsy
YF Bai, C Zeng, M Jia, B Xiao - Seizure, 2022 - Elsevier
Topiramate (TPM) is widely used as monotherapy or add-on therapy in adults and children
(aged 2 to 16 years) with primary generalized tonic-clonic seizures or focal-onset seizures …
(aged 2 to 16 years) with primary generalized tonic-clonic seizures or focal-onset seizures …
[HTML][HTML] Epilepsy surgery in the first six months of life: a systematic review and meta-analysis
Introduction Nearly one-third of all infants with epilepsy develop drug-resistant epilepsy.
Although epilepsy surgery is a well-established therapy across all age groups, there might …
Although epilepsy surgery is a well-established therapy across all age groups, there might …
A narrative review of the mechanisms and consequences of intermittent hypoxia and the role of advanced analytic techniques in pediatric autonomic disorders
Disorders of autonomic functions are typically characterized by disturbances in multiple
organ systems. These disturbances are often comorbidities of common and rare diseases …
organ systems. These disturbances are often comorbidities of common and rare diseases …
IQ changes after pediatric epilepsy surgery: a systematic review and meta-analysis
T Schmidlechner, M Zaddach, F Heinen, S Cornell… - Journal of …, 2024 - Springer
Objective This systematic review aimed to assess the intellectual outcome of children who
underwent surgery for epilepsy. Methods A systematic review of electronic databases was …
underwent surgery for epilepsy. Methods A systematic review of electronic databases was …