Protein kinases are a large family of approximately 530 highly conserved enzymes that
transfer a γ-phosphate group from ATP to a variety of amino acid residues, such as tyrosine …

Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription
factor that regulates the expression of over 500 genes involved in cellular transformation …

The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3)
inflammasome is a component of the inflammatory process, and its aberrant activation is …

Although Michael acceptors display a potent and broad spectrum of bioactivity, they have
largely been ignored in drug discovery because of their presumed indiscriminate reactivity …

Spinal cord injury (SCI) is a severe neurological disease; however, there is no effective
treatment for spinal cord injury. Neuroinflammation involves the activation of resident …

Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1β and-
18, which are important mediators of inflammation. Abnormal activation of the inflammasome …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Many of the inflammatory diseases are becoming common in aging society throughout the
world. The clinically used anti‐inflammatory drugs suffer from the disadvantage of side …