Nuclear factor κB (NF‐κB), a transcription factor, plays an important role in carcinogenesis
as well as in the regulation of immune and inflammatory responses. NF‐κB induces the …

Chemical probes represent versatile tools to validate disease-modifying targets. However,
evaluating the selectivity of chemical probes in complex cellular systems is a major …

Radiotherapy and chemotherapy are two famous modalities in tumor‐targeted therapy that
lead to systemic and local toxicities for normal tissues. Moreover, several studies have …

Biological electrophiles result from oxidative metabolism of exogenous compounds or
endogenous cellular constituents, and they contribute to pathophysiologies such as toxicity …

Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and
pathological apoptosis. Caspase-11 is not expressed in most tissues under normal …

The in vitro activity of parthenolide against Leishmania amazonensis was investigated.
Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial …

The transcription factor NF-κB is one of the main players involved in inflammatory responses
during which NF-κB becomes rapidly activated. However to maintain homeostasis, this NF …

Inhibitors of IκB kinase (IKK) have long been sought as specific regulators of NF-κB. A
screening effort of the endogenous IKK complex allowed us to identify 5-bromo-6-methoxy-β …

Sesquiterpene lactones (STLs) present a wide range of biological activities, mostly based on
their alkylating capabilities, which underlie their therapeutic potential. These compounds are …

The effective approach to discover innovative drugs will ask natural products for answers
because of their complex and changeable structures and multiple biological activities …