NF-κB signaling in cancer stem cells: a promising therapeutic target?

K Vazquez-Santillan, J Melendez-Zajgla… - Cellular oncology, 2015 - Springer
Abstract Background Cancer stem cells (CSCs) are regulated by several signaling pathways
that ultimately control their maintenance and expansion. NF-κB (nuclear factor kappa-light …

[HTML][HTML] Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis

D Carlisi, G Buttitta, R Di Fiore, C Scerri… - Cell death & …, 2016 - nature.com
Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma
associated with a high rate of recidivism. In this paper, we report the production of …

[HTML][HTML] Meaning and significance of “alkalization therapy for cancer”

H Wada, R Hamaguchi, R Narui, H Morikawa - Frontiers in Oncology, 2022 - frontiersin.org
Objectives of the Study Our research aims to answer the following questions. Can cancer
progression be stopped by changing the body condition of person with cancer? Can cancer …

Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

MH Teiten, F Gaascht, M Dicato, M Diederich - Biochemical pharmacology, 2013 - Elsevier
Since centuries, natural compounds from plants, animals and microorganisms were used in
medicinal traditions to treat various diseases without a solid scientific basis. Recent studies …

Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases

N Özenver, T Efferth - Pharmacological research, 2021 - Elsevier
The NLRP3 inflammasome holds a crucial role in innate immune responses. Pathogen-and
danger-associated molecular patterns may initiate inflammasome activation and following …

[HTML][HTML] Independent component analysis: mining microarray data for fundamental human gene expression modules

JM Engreitz, BJ Daigle Jr, JJ Marshall… - Journal of biomedical …, 2010 - Elsevier
As public microarray repositories rapidly accumulate gene expression data, these resources
contain increasingly valuable information about cellular processes in human biology. This …

Parthenolide inhibits tubulin carboxypeptidase activity

X Fonrose, F Ausseil, E Soleilhac, V Masson, B David… - Cancer research, 2007 - AACR
Microtubules are centrally involved in cell division, being the principal components of mitotic
spindle. Tubulin, the constituent of microtubules, can be cyclically modified on its α-subunit …

Structure–activity relationship of terpenes with anti‐inflammatory profile–A systematic review

MT de Santana Souza, JRGS Almeida… - Basic & clinical …, 2014 - Wiley Online Library
Inflammation is a complex biological response that in spite of having available treatments,
their side effects limit their usefulness. Because of this, natural products have been the …

NF-κB: arresting a major culprit in cancer

B Haefner - Drug Discovery Today, 2002 - Elsevier
Nuclear factor-κB (NF-κB) has long been known to play a central role in the immune system
by regulating the expression of key genes. Moreover, activation of this transcription factor …

Natural products as promising targets in glioblastoma multiforme: a focus on NF-κB signaling pathway

M Soukhtanloo, E Mohtashami, A Maghrouni… - Pharmacological …, 2020 - Springer
Background Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to
current medical interventions, particularly chemo/radiation. Hence, it necessitates further …