NF-κB signaling in cancer stem cells: a promising therapeutic target?
K Vazquez-Santillan, J Melendez-Zajgla… - Cellular oncology, 2015 - Springer
Abstract Background Cancer stem cells (CSCs) are regulated by several signaling pathways
that ultimately control their maintenance and expansion. NF-κB (nuclear factor kappa-light …
that ultimately control their maintenance and expansion. NF-κB (nuclear factor kappa-light …
[HTML][HTML] Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis
D Carlisi, G Buttitta, R Di Fiore, C Scerri… - Cell death & …, 2016 - nature.com
Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma
associated with a high rate of recidivism. In this paper, we report the production of …
associated with a high rate of recidivism. In this paper, we report the production of …
[HTML][HTML] Meaning and significance of “alkalization therapy for cancer”
H Wada, R Hamaguchi, R Narui, H Morikawa - Frontiers in Oncology, 2022 - frontiersin.org
Objectives of the Study Our research aims to answer the following questions. Can cancer
progression be stopped by changing the body condition of person with cancer? Can cancer …
progression be stopped by changing the body condition of person with cancer? Can cancer …
Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions
Since centuries, natural compounds from plants, animals and microorganisms were used in
medicinal traditions to treat various diseases without a solid scientific basis. Recent studies …
medicinal traditions to treat various diseases without a solid scientific basis. Recent studies …
Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases
N Özenver, T Efferth - Pharmacological research, 2021 - Elsevier
The NLRP3 inflammasome holds a crucial role in innate immune responses. Pathogen-and
danger-associated molecular patterns may initiate inflammasome activation and following …
danger-associated molecular patterns may initiate inflammasome activation and following …
[HTML][HTML] Independent component analysis: mining microarray data for fundamental human gene expression modules
JM Engreitz, BJ Daigle Jr, JJ Marshall… - Journal of biomedical …, 2010 - Elsevier
As public microarray repositories rapidly accumulate gene expression data, these resources
contain increasingly valuable information about cellular processes in human biology. This …
contain increasingly valuable information about cellular processes in human biology. This …
Parthenolide inhibits tubulin carboxypeptidase activity
X Fonrose, F Ausseil, E Soleilhac, V Masson, B David… - Cancer research, 2007 - AACR
Microtubules are centrally involved in cell division, being the principal components of mitotic
spindle. Tubulin, the constituent of microtubules, can be cyclically modified on its α-subunit …
spindle. Tubulin, the constituent of microtubules, can be cyclically modified on its α-subunit …
Structure–activity relationship of terpenes with anti‐inflammatory profile–A systematic review
MT de Santana Souza, JRGS Almeida… - Basic & clinical …, 2014 - Wiley Online Library
Inflammation is a complex biological response that in spite of having available treatments,
their side effects limit their usefulness. Because of this, natural products have been the …
their side effects limit their usefulness. Because of this, natural products have been the …
NF-κB: arresting a major culprit in cancer
B Haefner - Drug Discovery Today, 2002 - Elsevier
Nuclear factor-κB (NF-κB) has long been known to play a central role in the immune system
by regulating the expression of key genes. Moreover, activation of this transcription factor …
by regulating the expression of key genes. Moreover, activation of this transcription factor …
Natural products as promising targets in glioblastoma multiforme: a focus on NF-κB signaling pathway
M Soukhtanloo, E Mohtashami, A Maghrouni… - Pharmacological …, 2020 - Springer
Background Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to
current medical interventions, particularly chemo/radiation. Hence, it necessitates further …
current medical interventions, particularly chemo/radiation. Hence, it necessitates further …