The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …

Cancer immunotherapy is a type of treatment that harnesses the power of the immune
systems of patients to target cancer cells with better precision compared to traditional …

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that
is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit …

Sphingolipids are involved in cell signaling and metabolic pathways, and their metabolites
play a critical role in host defense against intracellular pathogens. Here, we review the …

Chimeric antigen receptor (CAR) T cells have shown promising results in the treatment of B-
cell malignancies. Despite the successes, challenges remain. One of them directly involves …

Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and
revolutionized the paradigm of tumor treatment, while substantial patients remain …

The initial excitement generated more than two decades ago by the discovery of drugs
targeting fatty acid synthase (FASN)‐catalyzed de novo lipogenesis for cancer therapy was …

The frequently occurring T cell mediated rejection (TCMR) is a risk factor for allograft failure.
Immunosuppressive therapy fails to reverse almost 40% of TCMRs occurring in human …