Pharmacologically active compounds that manipulate cellular senescence (senotherapies)
have recently shown great promise in multiple pre-clinical disease models, and some of …

Since therapy‐induced senescence (TIS) can either support or inhibit cancer progression,
identifying which types of chemotherapeutic agents can produce the strongest anti‐tumor …

The dysregulation of the cell cycle is one of the hallmarks of cancer. Cyclin-dependent
kinase 4 (CDK4) and CDK6 play crucial roles in regulating cell cycle and other cellular …

The use of cell cycle inhibitors has necessitated a better understanding of the cell cycle in
tumor biology to optimize the therapeutic approach. Cell cycle aberrations are common in …

Tumor cells can undergo diverse responses to cancer therapy. While apoptosis represents
the most desirable outcome, tumor cells can alternatively undergo autophagy and …

Simple Summary Nowadays, the upfront treatment for patients facing a diagnosis of
advanced luminal breast cancer (BC) is a combination of endocrine therapy (ET) with an …

Abstract Chronic angiotensin II (Ang II) stimulation induces vascular smooth muscle cell
(VSMC) senescence, and circRNAs and members of the ILF3 family are implicated in …

Cancer progression is continuously controlled by the immune system which can identify and
destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system …

Cyclin-dependent kinases (CDK) control the cell cycle and play a crucial role in
oncogenesis. Pharmacologic inhibition of CDK has contributed to the recent clinical …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …