Immune control by amino acid catabolism during tumorigenesis and therapy
Immune checkpoints arise from physiological changes during tumorigenesis that
reprogramme inflammatory, immunological and metabolic processes in malignant lesions …
reprogramme inflammatory, immunological and metabolic processes in malignant lesions …
Neuroinflammation and comorbidity of pain and depression
Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …
physical illness. Here, we critically examine the possibility that inflammation is the common …
Psychological processing in chronic pain: a neural systems approach
LE Simons, I Elman, D Borsook - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Our understanding of chronic pain involves complex brain circuits that include sensory,
emotional, cognitive and interoceptive processing. The feed-forward interactions between …
emotional, cognitive and interoceptive processing. The feed-forward interactions between …
Gut microbiota is critical for the induction of chemotherapy-induced pain
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients
undergoing chemotherapy. We found that gut microbiota promotes the development of …
undergoing chemotherapy. We found that gut microbiota promotes the development of …
[PDF][PDF] Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation
The kynurenine (Kyn) pathway is the major route for tryptophan (Trp) metabolism, and it
contributes to several fundamental biological processes. Trp is constitutively oxidized by …
contributes to several fundamental biological processes. Trp is constitutively oxidized by …
Neuroplasticity underlying the comorbidity of pain and depression
L Doan, T Manders, J Wang - Neural plasticity, 2015 - Wiley Online Library
Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …
Depression, meanwhile, can also adversely affect pain behaviors ranging from …
Role of inflammation in suicide: from mechanisms to treatment
L Brundin, EY Bryleva… - …, 2017 - nature.com
Suicidal behavior is complex and manifests because of a confluence of diverse factors. One
such factor involves dysregulation of the immune system, which has been linked to the …
such factor involves dysregulation of the immune system, which has been linked to the …
How to study anxiety and depression in rodent models of chronic pain?
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …
suffering from chronic pain. Over time, different tests and models have been developed in …
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …
evidence that peripheral systems are also involved in mood, stress vulnerability vs …
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality
C Bay-Richter, KR Linderholm, CK Lim… - Brain, behavior, and …, 2015 - Elsevier
Background Patients with depression and suicidality suffer from low-grade
neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2, 3-dioxygenase, an …
neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2, 3-dioxygenase, an …