[HTML][HTML] Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
Abstract Indoleamine-2, 3-dioxygenase (IDO) inhibitors have entered clinical trials based on
their ability to restore anti-tumor immunity in preclinical studies. However, the mechanisms …
their ability to restore anti-tumor immunity in preclinical studies. However, the mechanisms …
A dialogue between the immune system and brain, spoken in the language of serotonin
NL Baganz, RD Blakely - ACS chemical neuroscience, 2013 - ACS Publications
Neuropsychiatric disorders have long been linked to both immune system activation and
alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a …
alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a …
Role of the kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches
R Dantzer - Inflammation-associated depression: Evidence …, 2017 - Springer
Physically ill patients with chronic inflammation often present with symptoms of depression.
Our understanding of the pathophysiology of inflammation-associated depression has …
Our understanding of the pathophysiology of inflammation-associated depression has …
Stress induced microglial activation contributes to depression
B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
Activation of corticostriatal circuitry relieves chronic neuropathic pain
M Lee, TR Manders, SE Eberle, C Su… - Journal of …, 2015 - Soc Neuroscience
Neural circuits that determine the perception and modulation of pain remain poorly
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models
Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …
motivation, and/or deficits in reward-related learning, is a common feature of depression …
Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies
Abstract Treatment-resistant depression affects up to 20% of individuals suffering from major
depressive disorder (MDD). The medications currently available to treat depression …
depressive disorder (MDD). The medications currently available to treat depression …
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive …
Inflammation-related changes in the concentrations of kynurenine pathway metabolites
occur in depression secondary to medical conditions but are not firmly established in …
occur in depression secondary to medical conditions but are not firmly established in …
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia—significance for activation of the kynurenine pathway
L Schwieler, MK Larsson, E Skogh, ME Kegel… - Journal of Psychiatry and …, 2015 - jpn.ca
Background: Accumulating evidence indicates that schizophrenia is associated with brain
immune activation. While a number of reports suggest increased cytokine levels in patients …
immune activation. While a number of reports suggest increased cytokine levels in patients …
The molecular neurobiology of chronic pain–induced depression
The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …
the management of patients with multiple co-existing diseases. Among these comorbidities …