Background and Purpose Patients suffering from trigeminal neuralgia are often
accompanied by anxiety and depression. Microglia‐mediated neuroinflammation is involved …

Progression of major depression, a multifactorial disorder with a neuroinflammatory
signature, seems to be associated with the disruption of body allostasis. High rates of …

There is a considerable body of evidence indicating that chronic adverse experience,
especially chronic psychosocial stress/trauma, represents a major risk factor for the …

Evidence supports inflammatory involvement in mood and cognitive symptoms across
psychiatric, neurological and medical disorders; however, inflammation is not a sensitive or …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and
highly debilitating long-term illness. People with ME/CFS are typically unable to carry out …

Neuropathic pain is one of the most important clinical consequences of injury to the
somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved …

A growing number of studies are pointing out the need for a conceptual shift from a brain-
centered to a body-inclusive approach in mental health research. In this perspective, the link …

The comorbid prevalence of major depressive disorder (MDD) with obesity and type II
diabetes mellitus reflects the existence of a subset of individuals with a complex common …

Background: Because of the subjective nature of current pain assessments, limited efficacy
of treatment options and risks associated with opioid abuse and diversion, the need for …

Depression is a salient emotional feature of chronic pain. Depression alters the pain
threshold and impairs functional recovery. To date, however, there has been limited …