A proportion of depressed individuals show evidence of inflammation. Both animal, quasi-
experimental, and longitudinal studies indicate that inflammatory processes may play a …

Objectives. Active inflammatory responses play an important role in the pathogenesis of
depression. We hypothesized that the rapid antidepressant effect of ketamine is associated …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and
highly debilitating long-term illness. People with ME/CFS are typically unable to carry out …

The epidemiological studies report a high prevalence of mood disorders in patients with
chronic pain, and these consequences of pain can be preclinically modeled. This …

The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal
actors of the interplay between the nervous and the immune system due to their ability of …

Over 350 million individuals suffer from depression, a psychiatric illness classified as major
depressive disorder (MDD) with symptoms that include a loss of interest or pleasure in life …

Affective disorders and cognitive deficits are common comorbidities of chronic pain in the
clinical setting, which severely affect the quality of life of pain patients and impose a great …

Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

Background Current antidepressant therapy remains unsatisfactory due to its delayed
clinical onset of action and the heterogeneity of depression. Targeting disturbed …

Accumulating data have led to a re-conceptualization of depression that emphasizes the
role of immune-inflammatory processes, coupled to oxidative and nitrosative stress (O&NS) …