Role of kynurenine metabolism pathway activation in major depressive disorders
J Savitz - Inflammation-associated depression: Evidence …, 2017 - Springer
A proportion of depressed individuals show evidence of inflammation. Both animal, quasi-
experimental, and longitudinal studies indicate that inflammatory processes may play a …
experimental, and longitudinal studies indicate that inflammatory processes may play a …
The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus
N Wang, HY Yu, XF Shen, ZQ Gao, C Yang… - Upsala journal of …, 2015 - Taylor & Francis
Objectives. Active inflammatory responses play an important role in the pathogenesis of
depression. We hypothesized that the rapid antidepressant effect of ketamine is associated …
depression. We hypothesized that the rapid antidepressant effect of ketamine is associated …
[HTML][HTML] The role of kynurenine pathway and NAD+ metabolism in myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and
highly debilitating long-term illness. People with ME/CFS are typically unable to carry out …
highly debilitating long-term illness. People with ME/CFS are typically unable to carry out …
The anxiodepressive comorbidity in chronic pain
The epidemiological studies report a high prevalence of mood disorders in patients with
chronic pain, and these consequences of pain can be preclinically modeled. This …
chronic pain, and these consequences of pain can be preclinically modeled. This …
The distinct roles of monoamines in multiple sclerosis: A bridge between the immune and nervous systems?
T Carandini, M Cercignani, D Galimberti… - Brain, Behavior, and …, 2021 - Elsevier
The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal
actors of the interplay between the nervous and the immune system due to their ability of …
actors of the interplay between the nervous and the immune system due to their ability of …
[HTML][HTML] Insights into macrophage heterogeneity and cytokine-induced neuroinflammation in major depressive disorder
A Dey, PA Hankey Giblin - Pharmaceuticals, 2018 - mdpi.com
Over 350 million individuals suffer from depression, a psychiatric illness classified as major
depressive disorder (MDD) with symptoms that include a loss of interest or pleasure in life …
depressive disorder (MDD) with symptoms that include a loss of interest or pleasure in life …
Preclinical research on pain comorbidity with affective disorders and cognitive deficits: challenges and perspectives
MG Liu, J Chen - Progress in neurobiology, 2014 - Elsevier
Affective disorders and cognitive deficits are common comorbidities of chronic pain in the
clinical setting, which severely affect the quality of life of pain patients and impose a great …
clinical setting, which severely affect the quality of life of pain patients and impose a great …
Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?
Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …
Targeting hippocampal phospholipid and tryptophan metabolism for antidepressant-like effects of albiflorin
QS Wang, K Yan, KD Li, LN Gao, X Wang, H Liu… - Phytomedicine, 2021 - Elsevier
Background Current antidepressant therapy remains unsatisfactory due to its delayed
clinical onset of action and the heterogeneity of depression. Targeting disturbed …
clinical onset of action and the heterogeneity of depression. Targeting disturbed …
Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications
Accumulating data have led to a re-conceptualization of depression that emphasizes the
role of immune-inflammatory processes, coupled to oxidative and nitrosative stress (O&NS) …
role of immune-inflammatory processes, coupled to oxidative and nitrosative stress (O&NS) …