Cytosolic DNA sensing activates the stimulator of IFN genes (STING) adaptor to induce IFN
type I (IFN-αβ) production. Constitutive DNA sensing to induce sustained STING activation …

The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal
actors of the interplay between the nervous and the immune system due to their ability of …

In mammals, amino acid metabolism has evolved to act as a critical regulator of innate and
adaptive immune responses. Rheumatoid arthritis (RA) is the most common form of …

Interferon gamma (IFNγ) is a pro-inflammatory cytokine, first described as a secreted
molecule capable of interfering with viral replication. Since then, numerous other important …

Patients suffering from depression most commonly present with symptoms associated with
the autonomic nervous system. Despite the satisfactory results achieved following treatment …

Immune activation and inflammation are closely associated with the development of
depression. Pioglitazone (PIO), a peroxisome proliferator-activated receptor gamma (PPAR …

Depression is an incapacitating neuropsychiatric disorder. The serotonergic system in the
brain plays an important role in the pathophysiology of depression. However, due to delayed …

Depression and chronic pain have been estimated to co-occur in up to 80% of patients
suffering from these disorders, with this co-morbidity being more disabling and more …

Rationale Clinically, chronic postsurgical pain (CPSP) is very common. Many CPSP patients
may experience depression. Thus far, little is known about the mechanism of the comorbidity …

Despite the myriad promising new targets and candidate analgesics recently identified in
preclinical pain studies, little translation to novel pain medications has been generated. The …