Iv anaesthesia is limited by the fact that children dislike injections. However, in certain
circumstances, such as a child with a full stomach or a history of malignant hyperthermia, iv …

Indicator dilution theory predicts that the first-pass pulmonary and systemic arterial
concentrations of a drug will be inversely related to the cardiac output. For high-clearance …

Objective: The manual injection of a bolus of opioid in patients with brain injury induces an
increase in intracranial pressure related to a decrease in mean arterial pressure. Such an …

Objective To evaluate quality of anaesthetic induction and cardiorespiratory effects following
rapid intravenous (IV) injection of propofol or alfaxalone. Study design Prospective …

Background Propofol is one of the most widely used injectable anaesthetic agents in
veterinary practice. Cardiovascular effects related to propofol use in dogs remain less well …

Since venous cannulation in children has become easier and extensive experience has
been gained with total intravenous anaesthesia (TIVA) in adults, the interest in TIVA for …

Background CNS 7056 is an esterase-metabolized benzodiazepine sedative currently
under development. Its short duration of action would suggest a clinical role similar to …

Objective In this study, we compared the propofol–ketamine and propofol–remifentanil
combinations for deep sedation and analgesia during pediatric burn wound dressing …

The objective of this study was to determine the pharmacodynamic effects in sheep of the
anaesthetic alfaxalone in a 2-hydroxypropyl-β-cyclodextrin formulation. Seven Ripollesa …

Background AQUAVAN Injection (AQ)(GPI 15715; Guilford Pharmaceuticals Inc., Baltimore,
MD) is a water-soluble prodrug of propofol. The authors explored the pharmacodynamics …