▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …

Recent advances in the understanding of T cell activation have led to new therapeutic
approaches in the treatment of immunological disorders. One attractive target of intervention …

Abstract Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40
subunits. Analyses in vitro have defined IL-12 as an important factor for the differentiation of …

Dysregulated cytokine expression and signaling are major contributors to a number of
autoimmune diseases. Interleukin-17A (IL-17A) and IL-6 are important in many disorders …

Cytokines have crucial functions in the development, differentiation and regulation of
immune cells. As a result, dysregulation of cytokine production or action is thought to have a …

Abstract Indoleamine 2, 3-dioxygenase (IDO) degrades the indole moiety of tryptophan,
serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory …

Objective To investigate the prevalence of autoimmune thyroiditis (AIT) in patients with
polycystic ovary syndrome (PCOS). Design Over a period of 30 months, 175 patients with …

Abstract Although interleukin 12 (IL-12) production by dendritic cells (DCs) confers
protection against harmful invasions by regulating both innate and adaptive immunity, its …

Leukocytes enter sites of inflammation by squeezing through the borders between
endothelial cells that line postcapillary venules at that site. This rapid process, called …

Heart lesions of rheumatic heart disease (RHD) patients contain T-cell clones that recognize
heart proteins and streptococcal M peptides. To functionally characterize heart-infiltrating T …