The endoplasmic reticulum (ER) is an essential organelle involved in many cellular
functions including protein folding and secretion, lipid biosynthesis, and calcium …

The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a
wide range of cellular functions, including endoplasmic reticulum-associated degradation …

Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …

Protein misfolding, whether caused by aging, environmental factors, or genetic mutations, is
a common basis for neurodegenerative diseases. The misfolding of proteins with abnormally …

Slowly progressive ataxia accompanied by cerebellar degeneration is often genetic in
origin. The past 15 years have witnessed a revolution in our understanding of the causes of …

Spinocerebellar ataxia type 3 is a neurodegenerative disorder caused by the expansion of
the polyglutamine repeat region within the ataxin-3 protein. The mutant protein forms …

Ubiquitin chain complexity in cells is likely regulated by a diverse set of deubiquitinating
enzymes (DUBs) with distinct ubiquitin chain preferences. Here we show that the …

YOD1 is a highly conserved deubiquitinating enzyme of the ovarian tumor (otubain) family,
whose function has yet to be assigned in mammalian cells. YOD1 is a constituent of a …

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in
various diseases including cancer and neurodegeneration. In this review, we recapitulate …

The AAA-type ATPase Cdc48 (named p97/VCP in mammals) is a molecular machine in all
eukaryotic cells that transforms ATP hydrolysis into mechanic power to unfold and pull …