[HTML][HTML] Recent advances in p97/VCP/Cdc48 cellular functions
K Yamanaka, Y Sasagawa, T Ogura - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
p97/VCP/Cdc48 is one of the best-characterized type II AAA (ATPases associated with
diverse cellular activities) ATPases. p97 is suggested to be a ubiquitin-selective chaperone …
diverse cellular activities) ATPases. p97 is suggested to be a ubiquitin-selective chaperone …
Aggresome formation and neurodegenerative diseases: therapeutic implications
LS Chin, JA Olzmann, L Li - Current medicinal chemistry, 2008 - ingentaconnect.com
Accumulation of misfolded proteins in proteinaceous inclusions is a prominent pathological
feature common to many agerelated neurodegenerative diseases, including Parkinson's …
feature common to many agerelated neurodegenerative diseases, including Parkinson's …
Inhibition of p97-dependent protein degradation by Eeyarestatin I
Q Wang, L Li, Y Ye - Journal of Biological Chemistry, 2008 - ASBMB
Elimination of misfolded proteins from the endoplasmic reticulum (ER) by ER-associated
degradation involves substrate retrotranslocation from the ER lumen into the cytosol for …
degradation involves substrate retrotranslocation from the ER lumen into the cytosol for …
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP
The mechanisms by which ubiquitin ligases are regulated remain poorly understood. Here
we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective …
we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective …
Emerging roles for ubiquitin and protein degradation in neuronal function
JY Jason, MD Ehlers - Pharmacological reviews, 2007 - ASPET
Alterations in cellular structure and synapse composition are central to proper nervous
system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key …
system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key …
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin‐3
Deubiquitinating enzymes (DUBs) control the ubiquitination status of proteins in various
cellular pathways. Regulation of the activity of DUBs, which is critically important to cellular …
cellular pathways. Regulation of the activity of DUBs, which is critically important to cellular …
Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases
S Chu, X Xie, C Payan, U Stochaj - Molecular Neurodegeneration, 2023 - Springer
The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …
Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin
L Lemus, V Goder - Cells, 2014 - mdpi.com
Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-
mediated assistance in folding and the selective targeting of terminally misfolded species to …
mediated assistance in folding and the selective targeting of terminally misfolded species to …
Polyglutamine diseases: the special case of ataxin-3 and Machado–Joseph disease
Polyglutamine (polyQ) diseases are a group of nine neurodegenerative disorders caused by
an unstable CAG expansion in the codifying region of their respective associated genes …
an unstable CAG expansion in the codifying region of their respective associated genes …
The ER‐resident ubiquitin‐specific protease 19 participates in the UPR and rescues ERAD substrates
GC Hassink, B Zhao, R Sompallae, M Altun… - EMBO …, 2009 - embopress.org
Ubiquitination regulates membrane events such as endocytosis, membrane trafficking and
endoplasmic‐reticulum‐associated degradation (ERAD). Although the involvement of …
endoplasmic‐reticulum‐associated degradation (ERAD). Although the involvement of …