p97/VCP/Cdc48 is one of the best-characterized type II AAA (ATPases associated with
diverse cellular activities) ATPases. p97 is suggested to be a ubiquitin-selective chaperone …

Accumulation of misfolded proteins in proteinaceous inclusions is a prominent pathological
feature common to many agerelated neurodegenerative diseases, including Parkinson's …

Elimination of misfolded proteins from the endoplasmic reticulum (ER) by ER-associated
degradation involves substrate retrotranslocation from the ER lumen into the cytosol for …

The mechanisms by which ubiquitin ligases are regulated remain poorly understood. Here
we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective …

Alterations in cellular structure and synapse composition are central to proper nervous
system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key …

Deubiquitinating enzymes (DUBs) control the ubiquitination status of proteins in various
cellular pathways. Regulation of the activity of DUBs, which is critically important to cellular …

The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …

Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-
mediated assistance in folding and the selective targeting of terminally misfolded species to …

Polyglutamine (polyQ) diseases are a group of nine neurodegenerative disorders caused by
an unstable CAG expansion in the codifying region of their respective associated genes …

Ubiquitination regulates membrane events such as endocytosis, membrane trafficking and
endoplasmic‐reticulum‐associated degradation (ERAD). Although the involvement of …