The nuclear presence of the expanded disease proteins is of critical importance for the
pathogeneses of polyglutamine diseases. Here we show that protein casein kinase 2 (CK2) …

Molecular chaperones and their associated cofactors form a group of highly specialized
proteins that orchestrate the folding and unfolding of other proteins and the assembly and …

The Ubiquitin-Proteasome Pathway (UPP), which is critical for normal function in the
nervous system and is implicated in various neurological diseases, requires the small …

The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

Eukaryotic cells are constantly exposed to both endogenous and exogenous stressors that
promote the induction of DNA damage. Of this damage, double strand breaks (DSBs) are the …

Deubiquitinating enzymes (DUbs) play important roles in many ubiquitin-dependent
pathways, yet how DUbs themselves are regulated is not well understood. Here, we provide …

Most proteins in the secretory pathway are translated, folded, and subjected to quality
control at the endoplasmic reticulum (ER). These processes must be flexible enough to …

Machado–Joseph disease (MJD, also known as spinocerebellar ataxia type 3, SCA3), an
autosomal dominant neurological disorder, is caused by an abnormal expanded …

The carboxy‐terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase
containing three tandem repeats of tetratricopeptide (TPR) motifs and a C‐terminal U‐box …

The AAA-ATPase Cdc48/p97 controls a large array of cellular functions including protein
degradation, cell division, membrane fusion through its ability to interact with and control the …