Quercetin glycosides, rutin and isoquercitrin, are potent antioxidants that have been found to
possess neuroprotective effect in diseases like Parkinson's and Alzheimer's disease. In the …

Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins
synthesized in the ER. Through coordinated actions of ERAD components …

Apolipoprotein B (apoB) is the main protein component of very low density lipoprotein
(VLDL) and is necessary for the assembly and secretion of these triglyceride (TG)-rich …

Ataxin-3 (ATXN3) is a widely expressed protein that binds to ubiquitylated proteins, has
deubiquitylating activity in vitro and is thought to modulate substrate degradation through the …

Machado‐Joseph disease (MJD) is the most common dominant spinocerebellar ataxia. MJD
is caused by a CAG trinucleotide expansion in the ATXN3 gene, which encodes a protein …

p97 is a homohexameric, toroidal machine that harnesses the energy of ATP binding and
hydrolysis to effect structural reorganization of a diverse and primarily uncharacterized set of …

Ataxin-3 is a deubiquitinase and polyglutamine (polyQ) disease protein with a protective role
in Drosophila melanogaster models of neurodegeneration. In the fruit fly, wild-type ataxin-3 …

The spinocerebellar ataxias (SCA) comprise a group of inherited neurodegenerative
diseases. SCA3 is the most common form, caused by the expansion of CAG repeats within …

To maintain protein homeostasis in the ER, an ER protein quality control system retains
unfolded polypeptides and misassembled membrane proteins, allowing only properly folded …

Polyglutamine (polyQ) repeat-containing proteins are widespread in the human proteome
but only nine of them are associated with highly incapacitating neurodegenerative disorders …