In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

Gingival tissues are attacked by oral pathogens which can induce inflammatory reactions.
The immune-inflammatory responses play essential roles in the patient susceptibility to …

Helicobacter pylori is known as an important determinant of preneoplastic lesions or gastric
cancer (GC) risk. The bacterial genotypes may determine the clinical outcomes. However …

Chronic inflammation plays a decisive role at different stages of cancer development.
Inflammasomes are oligomeric protein complexes activated in response to pathogen …

Nowadays, gastric cancer is one of the most common neoplasms and the fourth cause of
cancer-related death on the world. Regarding the age at the diagnosis it is divided into early …

The Hippo pathway plays an important role in cell proliferation, apoptosis, and
differentiation; it is a crucial regulatory pathway in organ development and tumor growth …

Helicobacter pylori persistently colonizes the human stomach, and is associated with
inflammation-induced gastric cancer. Bacterial crosstalk with the host immune system …

Background With the essential role of interleukin-1 signaling in cancer-related inflammation,
IL-1R1, the main receptor for both IL-1α and IL-1β, demonstrated therapeutic potential in …