Reaction mechanisms and kinetics of nanozymes: insights from theory and computation

X Shen, Z Wang, XJ Gao, X Gao - Advanced Materials, 2024 - Wiley Online Library
Abstract “Nanozymes” usually refers to inorganic nanomaterials with enzyme‐like catalytic
activities. The research into nanozymes is one of the hot topics on the horizon of …

Dopamine and levodopa prodrugs for the treatment of Parkinson's disease

F Haddad, M Sawalha, Y Khawaja, A Najjar… - Molecules, 2017 - mdpi.com
Background: Parkinson's disease is an aggressive and progressive neurodegenerative
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …

[HTML][HTML] Recent advances in prodrug-based nanoparticle therapeutics

KJ Chen, AJ Plaunt, FG Leifer, JY Kang… - European Journal of …, 2021 - Elsevier
Extensive research into prodrug modification of active pharmaceutical ingredients and
nanoparticle drug delivery systems has led to unprecedented levels of control over the …

Carbamate group as structural motif in drugs: A review of carbamate derivatives used as therapeutic agents

A Matošević, A Bosak - Archives of Industrial Hygiene and Toxicology, 2020 - sciendo.com
Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes,
and resemblance to a peptide bond, carbamate derivatives have received much attention in …

Antibacterial prodrugs to overcome bacterial resistance

B Jubeh, Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Bacterial resistance to present antibiotics is emerging at a high pace that makes the
development of new treatments a must. At the same time, the development of novel …

Mutual prodrugs of 5‐fluorouracil: From a classic chemotherapeutic agent to novel potential anticancer drugs

V Ciaffaglione, MN Modica, V Pittalà, G Romeo… - …, 2021 - Wiley Online Library
The development of potent antitumor agents with a low toxicological profile against healthy
cells is still one of the greatest challenges facing medicinal chemistry. In this context, the …

Biomedical applications of aromatic azo compounds

Y Ali, SA Hamid, U Rashid - Mini reviews in medicinal …, 2018 - ingentaconnect.com
Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries.
Besides their characteristic coloring function, azo compounds are reported as antibacterial …

The prodrug approach in the era of drug design

A Najjar, R Karaman - Expert opinion on drug delivery, 2019 - Taylor & Francis
Prodrugs are inactive precursors of an active drug designed to be bioconverted (activated)
post administration with the main aim of improving the pharmacokinetic properties of the …

Functional peptide-based drug delivery systems

Z Lian, T Ji - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Peptides are one of the most important functional motifs for constructing smart drug delivery
systems (DDSs). Functional peptides can be conjugated with drugs or carriers via covalent …

Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents

MS Raghu, CBP Kumar, KY Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …