Reaction mechanisms and kinetics of nanozymes: insights from theory and computation
X Shen, Z Wang, XJ Gao, X Gao - Advanced Materials, 2024 - Wiley Online Library
Abstract “Nanozymes” usually refers to inorganic nanomaterials with enzyme‐like catalytic
activities. The research into nanozymes is one of the hot topics on the horizon of …
activities. The research into nanozymes is one of the hot topics on the horizon of …
Dopamine and levodopa prodrugs for the treatment of Parkinson's disease
F Haddad, M Sawalha, Y Khawaja, A Najjar… - Molecules, 2017 - mdpi.com
Background: Parkinson's disease is an aggressive and progressive neurodegenerative
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …
[HTML][HTML] Recent advances in prodrug-based nanoparticle therapeutics
KJ Chen, AJ Plaunt, FG Leifer, JY Kang… - European Journal of …, 2021 - Elsevier
Extensive research into prodrug modification of active pharmaceutical ingredients and
nanoparticle drug delivery systems has led to unprecedented levels of control over the …
nanoparticle drug delivery systems has led to unprecedented levels of control over the …
Carbamate group as structural motif in drugs: A review of carbamate derivatives used as therapeutic agents
A Matošević, A Bosak - Archives of Industrial Hygiene and Toxicology, 2020 - sciendo.com
Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes,
and resemblance to a peptide bond, carbamate derivatives have received much attention in …
and resemblance to a peptide bond, carbamate derivatives have received much attention in …
Antibacterial prodrugs to overcome bacterial resistance
B Jubeh, Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Bacterial resistance to present antibiotics is emerging at a high pace that makes the
development of new treatments a must. At the same time, the development of novel …
development of new treatments a must. At the same time, the development of novel …
Mutual prodrugs of 5‐fluorouracil: From a classic chemotherapeutic agent to novel potential anticancer drugs
V Ciaffaglione, MN Modica, V Pittalà, G Romeo… - …, 2021 - Wiley Online Library
The development of potent antitumor agents with a low toxicological profile against healthy
cells is still one of the greatest challenges facing medicinal chemistry. In this context, the …
cells is still one of the greatest challenges facing medicinal chemistry. In this context, the …
Biomedical applications of aromatic azo compounds
Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries.
Besides their characteristic coloring function, azo compounds are reported as antibacterial …
Besides their characteristic coloring function, azo compounds are reported as antibacterial …
The prodrug approach in the era of drug design
A Najjar, R Karaman - Expert opinion on drug delivery, 2019 - Taylor & Francis
Prodrugs are inactive precursors of an active drug designed to be bioconverted (activated)
post administration with the main aim of improving the pharmacokinetic properties of the …
post administration with the main aim of improving the pharmacokinetic properties of the …
Functional peptide-based drug delivery systems
Z Lian, T Ji - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Peptides are one of the most important functional motifs for constructing smart drug delivery
systems (DDSs). Functional peptides can be conjugated with drugs or carriers via covalent …
systems (DDSs). Functional peptides can be conjugated with drugs or carriers via covalent …
Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents
To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …