Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
CL Masters, DJ Selkoe - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …
Insights into Aβ aggregation: A molecular dynamics perspective
This article reviews recent molecular dynamics simulations of the Alzheimer's amyloid-β
protein, the primary component of the amyloid plaques found in the brain of Alzheimer's …
protein, the primary component of the amyloid plaques found in the brain of Alzheimer's …
Nanopore analysis of β-amyloid peptide aggregation transition induced by small molecules
β-Amyloid 42 (Aβ42) is the predominant form of the amyloid peptide, which is found in the
plaques of the brains of Alzheimer's (AD) patients and is one of the most abundant …
plaques of the brains of Alzheimer's (AD) patients and is one of the most abundant …
Dimer formation enhances structural differences between amyloid β-protein (1–40) and (1–42): an explicit-solvent molecular dynamics study
Amyloid-protein (A) is central to the pathology of Alzheimer's disease. A 5% difference in the
primary structure of the two predominant alloforms, A and A, results in distinct assembly …
primary structure of the two predominant alloforms, A and A, results in distinct assembly …
Discrete molecular dynamics study of oligomer formation by N-terminally truncated amyloid b-protein
Alzheimer's disease (AD) is strongly linked to amyloid b-protein (Ab). Two predominant
alloforms, Ab1− 40 and in particular Ab1− 42, are known to form toxic oligomers. The N …
alloforms, Ab1− 40 and in particular Ab1− 42, are known to form toxic oligomers. The N …
Molecular dynamics simulation and MM–PBSA calculations of sickle cell hemoglobin in dimer form with Val, Trp, or Phe at the lateral contact
H Abroshan, H Akbarzadeh… - Journal of Physical …, 2010 - Wiley Online Library
Sickle cell anemia reflects a single change in the amino acid building blocks of the oxygen-
transport protein, hemoglobin. The beta subunits have the neutral hydrophobic amino acid …
transport protein, hemoglobin. The beta subunits have the neutral hydrophobic amino acid …
The structure of intrinsically disordered peptides implicated in amyloid diseases: insights from fully atomistic simulations
Protein aggregation involves the self-assembly of proteins into large β-sheet-rich
complexes. This process can be the result of aberrant protein folding and lead to …
complexes. This process can be the result of aberrant protein folding and lead to …
[图书][B] Molecular Dynamics Studies of Intrinsically Disordered Peptides and Proteins
D Meral - 2015 - search.proquest.com
Intrinsically disordered proteins (IDPs) can present in a variety of forms, including flexible
and extended structures, compact molten-globules, or mixtures of the two. Furthermore …
and extended structures, compact molten-globules, or mixtures of the two. Furthermore …