The hallmark clinical symptom of early Alzheimer's disease (AD) is episodic memory
impairment. Recent functional imaging studies suggest that memory function is subserved …

It has previously been shown that low-frequency fluctuations in both respiratory volume and
cardiac rate can induce changes in the blood-oxygen level dependent (BOLD) signal. Such …

In this article, marking the 65th anniversary of the Journal of Gerontology, we offer a broad-
brush overview of the new synthesis between neuroscientific and psychological approaches …

Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23
patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied …

The default mode network (DMN) supports memory functioning and may be sensitive to
preclinical Alzheimer's pathology. Little is known, however, about the longitudinal trajectory …

Recently, both increases and decreases in resting-state functional connectivity have been
found in major depression. However, these studies only assessed functional connectivity …

Amyloid deposition is present in 20–50% of nondemented older adults yet the functional
consequences remain unclear. The current study found that amyloid accumulation is …

Greater physical activity and cardiorespiratory fitness are associated with reduced age-
related cognitive decline and lower risk for dementia. However, significant gaps remain in …

The characterization of topological architecture of complex brain networks is one of the most
challenging issues in neuroscience. Slow (< 0.1 Hz), spontaneous fluctuations of the blood …

The human brain undergoes both morphological and functional modifications across the
human lifespan. It is important to understand the aspects of brain reorganization that are …