Exploring the enhanced antiproliferative activity of turmeric oil and 6-mercaptopurine in a combined nano-particulate system formulation
6-Mercaptopurine (6-MP) is a chemotherapeutic agent with inadequate efficacy due to its
poor aqueous solubility and limited bioavailability. Turmeric oil is a naturally occurring …
poor aqueous solubility and limited bioavailability. Turmeric oil is a naturally occurring …
Self-double-emulsifying drug delivery system enteric-coated capsules: a novel approach to improve oral bioavailability and anti-inflammatory activity of Panax …
Y Wang, Y Shang, F Tang, K Qiu, X Wei, Z Wang - AAPS PharmSciTech, 2023 - Springer
In this work, self-double-emulsifying drug delivery system enteric-coated capsules (PNS-
SDE-ECC) were used to enhance the oral bioavailability and anti-inflammatory effects of …
SDE-ECC) were used to enhance the oral bioavailability and anti-inflammatory effects of …
The effects of doxorubicin loaded aptamer S3-linked DNA tetrahedrons on nasopharyngeal carcinoma
X Liu, B Jiang, A Cheng, Y Guo… - … -Head & Neck …, 2023 - journals.sagepub.com
Objective Our research group in the early stage identified CD109 as the target of aptamer S3
in nasopharyngeal carcinoma (NPC). This study was to use S3 to connect DNA tetrahedron …
in nasopharyngeal carcinoma (NPC). This study was to use S3 to connect DNA tetrahedron …
Discovery and biological evaluation of pregnenolone selenocyanoamides with potential anticancer and antimicrobial activities
Y Huang, W Tian, Z Peng, Y Cheng, M Wei, Z Liu… - The Journal of Steroid …, 2023 - Elsevier
Starting with pregnenolone, a 20-carbonyl group was converted into an amino group
through a series of chemical reactions. This amino group was further converted into …
through a series of chemical reactions. This amino group was further converted into …
2-Methoxyestradiol ameliorates doxorubicin-induced cardiotoxicity by regulating the expression of GLUT4 and CPT-1B in female rats
The clinical usage of doxorubicin (DOX) is hampered due to cardiomyopathy. Studies reveal
that estrogen (E2) modulates DOX-induced cardiotoxicity. Yet, the exact mechanism is …
that estrogen (E2) modulates DOX-induced cardiotoxicity. Yet, the exact mechanism is …
Intestinal absorption studies of ORI-SMEDDS with different zeta potentials through lipolysis absorption model in vitro, single pass intestine perfusion and …
L Wang, B Zhu, W Lu, Q Zhang, W Fang, S Gao… - Journal of Drug Delivery …, 2023 - Elsevier
Self-microemulsion drug delivery system (SMEDDS) is always applied to enhance the
solubility of hydrophobic and lipophilic drugs. In recent years, the technology has been used …
solubility of hydrophobic and lipophilic drugs. In recent years, the technology has been used …
2-甲氧基雌二醇对新生大鼠缺氧性肺动脉高压的保护作用.
谢鸥， 李珊珊， 罗洋， 王乐 - Chinese Journal of …, 2024 - search.ebscohost.com
目的探讨2-甲氧基雌二醇(2-methoxyestradiol, 2ME) 在新生大鼠缺氧性肺动脉高压中的保护
作用. 方法96 只Wistar 新生大鼠随机分为常氧组, 缺氧组和缺氧+ 2ME 组, 每组随机分为3 d, 7 …
作用. 方法96 只Wistar 新生大鼠随机分为常氧组, 缺氧组和缺氧+ 2ME 组, 每组随机分为3 d, 7 …
Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells
SD Al-Qahtani, HH Bin-Melaih, EM Atiya, UA Fahmy… - Life, 2022 - mdpi.com
(1) Background: 2-Methoxyestradiol (2ME) is a metabolite of estrogens and possesses
promising anti-proliferative and cytotoxic activities. However, it suffers unfavorable …
promising anti-proliferative and cytotoxic activities. However, it suffers unfavorable …