Epigenetic basis of mental illness
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …
neural circuit structure and function as well as likely abnormalities in glial cells. While …
Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder
AG Cardno, MJ Owen - Schizophrenia bulletin, 2014 - academic.oup.com
There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …
The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia
While the dopamine hypothesis has dominated schizophrenia research for several decades,
more recent studies have highlighted the role of fast synaptic transmitters and their receptors …
more recent studies have highlighted the role of fast synaptic transmitters and their receptors …
Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease
Abstract Cardiovascular (CV)-and lifestyle-associated risk factors (RFs) are increasingly
recognized as important for Alzheimer's disease (AD) pathogenesis. Beyond the ε4 allele of …
recognized as important for Alzheimer's disease (AD) pathogenesis. Beyond the ε4 allele of …
Genetic association between schizophrenia and cortical brain surface area and thickness
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …
variants, each with a small effect. While cortical differences between patients with …
Genetic contributions to bipolar disorder: current status and future directions
KS O'Connell, BJ Coombes - Psychological Medicine, 2021 - cambridge.org
Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …
million people worldwide. Our understanding of the genetic etiology of BD has greatly …
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
The hippocampus is a heterogeneous structure, comprising histologically distinguishable
subfields. These subfields are differentially involved in memory consolidation, spatial …
subfields. These subfields are differentially involved in memory consolidation, spatial …
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in …
Patients with schizophrenia have consistently shown brain volumetric abnormalities,
implicating both etiological and pathological processes. However, the genetic relationship …
implicating both etiological and pathological processes. However, the genetic relationship …
Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function
Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …
cognitive deficits are one of the factors most strongly associated with functional outcome in …