Cancer still represents a “nightmare” worldwide, causing annually millions of victims.
Several antiproliferative molecules are currently used as drugs market and offer a …

Cancer is a black spot on the face of humanity in this era of science and technology.
Presently, several classes of anticancer drugs are available in the market, but issues such …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The antibody drug conjugate platform and why it has not reached the potential of this
technology. Antibody drug conjugates are complex delivery systems for selective delivery of …

On the basis of preclinical studies that show overexpression of class III β-tubulin is
associated with resistance to tubulin-binding agents, several investigators have addressed …

Purpose: Microtubules are important cytoskeletal components involved in many cellular
events. Antimicrotubule agents including polymerizing agents (paclitaxel and docetaxel) and …

The vinca alkaloids have been used in the treatment of cancer for over 40 years. Their
efficacy has ensured that they remain among the drugs of choice for a number of human …

Tubulin poisons were first discovered decades ago, but the recent clinical and commercial
success of Taxol® has led to a renaissance in the search for novel mitotic spindle poisons to …

Cisplatin and carboplatin are active in previously untreated patients with metastatic breast
cancer (MBC) with mean response rates (RRs) of 50 and 32%, respectively. In pretreated …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …