The treatment of advanced non-small-cell lung cancer (NSCLC is based on the combination
of platin and one of the following agents: taxanes, gemcitabine, vinorelbine or irinotecan …

Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and
biophysical properties have made α-and β-tubulin, the main components of MTs, the subject …

Abstract N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid (D-24851) is a novel
synthetic compound that was identified in a cell-based screening assay to discover cytotoxic …

Vinca alkaloids including vincristine, vinblastine, vindesine, and vinflunine are
chemotherapeutic compounds commonly used to treat various cancers. Vinca alkaloids are …

Docetaxel (Taxotere) is a member of the taxane class of anticancer agents to reach clinical
use. This semisynthetic analog of paclitaxel (Taxol) is one of the newer potent anti …

Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been
used clinically for the prevention and treatment of cerebrovascular disorders and …

BACKGROUND Vinca alkaloids have proved active against a number of pediatric
malignancies. The aim of this study was to assess the feasibility and effectiveness of using …

Vinorelbine is an antimitotic anticancer agent and its main mechanism of action is related to
the inhibition of microtubule dynamics leading to a mitotic arrest and cell death. Vinorelbine …

Prostate cancer is the third leading cause of cancer-related death in men in the United
States. Taxane chemotherapy is a staple therapy for men with metastatic prostate cancer, yet …

Antibody drug conjugates (ADCs) represent a promising and an efficient strategy for
targeted cancer therapy. Comprised of a monoclonal antibody, a cytotoxic drug, and a linker …