Photobleaching of organic fluorophores: quantitative characterization, mechanisms, protection

AP Demchenko - Methods and applications in fluorescence, 2020 - iopscience.iop.org
Photochemical stability is one of the most important parameters that determine the
usefulness of organic dyes in different applications. This Review addresses key factors that …

Recent advances in bioprobes and biolabels based on cyanine dyes

X Ma, L Shi, B Zhang, L Liu, Y Fu, X Zhang - Analytical and bioanalytical …, 2022 - Springer
As a functional dye, cyanine dye promotes the widespread application of bioprobes in the
fields of medicine, genetics and environment, owing to its advantages of good photophysical …

Stability enhancement of fluorophores for lighting up practical application in bioimaging

X Wu, W Zhu - Chemical Society Reviews, 2015 - pubs.rsc.org
The practical application of organic fluorophores in bioimaging is severely limited due to
their generally poor stability. In this Highlight, we emphasize several representative …

Dicationic styryl dyes for colorimetric and fluorescent detection of nucleic acids

K Supabowornsathit, K Faikhruea, B Ditmangklo… - Scientific Reports, 2022 - nature.com
Nucleic acid staining dyes are important tools for the analysis and visualizing of DNA/RNA in
vitro and in the cells. Nevertheless, the range of commercially accessible dyes is still rather …

Ligand-induced G-quadruplex polymorphism: a DNA nanodevice for label-free aptasensor platforms

PS Deore, MD Gray, AJ Chung… - Journal of the American …, 2019 - ACS Publications
G-Quadruplexes (GQs) serve as popular recognition elements for DNA aptasensors and are
incorporated into a DNA nanodevice capable of controlled conformational changes to …

Hybridization-Sensitive Fluorescent Probes for DNA and RNA by a Modular “Click” Approach

J Gebhard, L Hirsch, C Schwechheimer… - Bioconjugate …, 2022 - ACS Publications
Fluorescent DNA probes were prepared in a modular approach using the “click” post-
synthetic modification strategy. The new glycol-based module and DNA building block place …

Two‐Factor Fluorogenicity of Tetrazine‐Modified Cyanine‐Styryl Dyes for Bioorthogonal Labelling of DNA

P Geng, E List, F Rönicke… - Chemistry–A European …, 2023 - Wiley Online Library
Two green fluorescent tetrazine‐modified cyanine‐styryl dyes were synthesized for
bioorthogonal labelling of DNA by means of the Diels‐Alder reaction with inverse electron …

A new structure–activity relationship for cyanine dyes to improve photostability and fluorescence properties for live cell imaging

C Schwechheimer, F Rönicke, U Schepers… - Chemical …, 2018 - pubs.rsc.org
A new set of cyanine-indole dyes was synthesized, characterized by optical and cytotoxic
properties and subsequently applied for live cell imaging. Furthermore, these dyes were …

Cationic styryl dyes for DNA labelling and selectivity toward cancer cells and Gram-negative bacteria

S Wangngae, U Ngivprom, T Khrootkaew… - RSC …, 2023 - pubs.rsc.org
Fluorescence-based methods are important tools for the analysis of nucleic acids in vitro
and in cells. In this study, two cationic cyanine–styryl derivatives were produced using a two …

On-strand knoevenagel insertion of a hemicyanine molecular rotor loop residue for turn-on fluorescence detection of Pb-induced G-quadruplex rigidity

RE Johnson, AJ Van Riesen… - Bioconjugate …, 2021 - ACS Publications
We demonstrate the ability to distinguish Pb2+ from K+ within the central cavity of the
antiparallel G-quadruplex (GQ) DNA produced by the thrombin binding aptamer (TBA) using …