The one health perspective to improve environmental surveillance of zoonotic viruses: lessons from COVID-19 and outlook beyond
The human population has doubled in the last 50 years from about 3.7 billion to
approximately 7.8 billion. With this rapid expansion, more people live in close contact with …
approximately 7.8 billion. With this rapid expansion, more people live in close contact with …
Key viral adaptations preceding the AIDS pandemic
D Sauter, F Kirchhoff - Cell host & microbe, 2019 - cell.com
HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …
species transmissions and recombination events as well as changes in the repertoire and …
CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein
CpG dinucleotide suppression has been reported to allow HIV-1 to evade inhibition by the
zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked …
zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked …
Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists
E Hagelauer, R Lotke, D Kmiec, D Hu, M Hohner… - Viruses, 2023 - mdpi.com
Coronavirus infection induces interferon-stimulated genes, one of which encodes Tetherin, a
transmembrane protein inhibiting the release of various enveloped viruses from infected …
transmembrane protein inhibiting the release of various enveloped viruses from infected …
Toward a macaque model of HIV-1 infection: Roadblocks, progress, and future strategies
The human-specific tropism of Human Immunodeficiency Virus Type 1 (HIV-1) has
complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for …
complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for …
Structural basis for tetherin antagonism as a barrier to zoonotic lentiviral transmission
CZ Buffalo, CM Stürzel, E Heusinger, D Kmiec… - Cell host & …, 2019 - cell.com
Tetherin is a host defense factor that physically prevents virion release from the plasma
membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the …
membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the …
SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid …
SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate
lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance …
lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance …
Slow receptor binding of the noncytopathic HIV-2UC1 Envs is balanced by long-lived activation state and efficient fusion activity
M Harris, S Ratnapriya, A Chov, H Cervera, A Block… - Cell reports, 2020 - cell.com
Many HIV strains downregulate the levels of CD4 receptor on the surface of infected cells to
prevent superinfection. In contrast, the rare HIV-2 UC1 strain is noncytopathic and has no …
prevent superinfection. In contrast, the rare HIV-2 UC1 strain is noncytopathic and has no …
In vivo Infection Dynamics and Human Adaptive Changes of SIVsm-Derived Viral Siblings SIVmac239, SIVB670, and SIVhu in Humanized Mice as a Paralog of HIV …
JZ Curlin, K Schmitt, L Remling-Mulder… - Frontiers in …, 2021 - frontiersin.org
Simian immunodeficiency virus native to sooty mangabeys (SIVsm) is believed to have
given rise to HIV-2 through cross-species transmission and evolution in the human …
given rise to HIV-2 through cross-species transmission and evolution in the human …
APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans
Simian immunodeficiency virus infecting sooty mangabeys (SIVsmm) has been transmitted
to humans on at least nine occasions, giving rise to human immunodeficiency virus type 2 …
to humans on at least nine occasions, giving rise to human immunodeficiency virus type 2 …